New stem cell therapy 'can help repair brain damage after stroke'

Scientific Developments/Breakthroughs

A new stem cell-based treatment for stroke has been developed that can help reduce brain damage and accelerate the brain's natural healing functions.

Researchers from the University of Georgia, Augusta University and ArunA Biomedical have created a treatment called AB126 using extracellular vesicles, a type of exosome generated from human neural stem cells.

“A stem-cell based stroke treatment has shown potential to help repair damaged brain tissue.“

This treatment is able to disguise itself from even the body's own defences within the bloodstream, and can carry and deliver multiple doses, with the tiny tubular shape of the exosomes making it possible to cross barriers that cells cannot.

A dose of AB126 applied to animal test models was associated with an approximately 35 percent decrease in the size of the stroke-induced brain injury, as well as a 50 percent reduction in brain tissue loss.

University of Georgia professor Steven Stice said: "Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function. Just days after stroke, we saw better mobility, improved balance and measurable behavioural benefits in treated animal models."

The team now hopes to evaluate this treatment's potential benefits in preclinical studies for epilepsy and traumatic brain and spinal cord injuries later this year.

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