Mouth ulcers and lesions treatment with electrospun biodegradable bandages

Service Engineering

Scientists at Sheffield University’s School of Clinical Dentistry and Dermtreat A/S have developed an alternative to the ointments and mouthwashes currently used to treat ulcers and lesions inside the mouth. They have created mucoadhesive patches using electrospinning to create biodegradable bandages that stick to the mouth and release steroids directly to oral ulcers or lesions. This process also creates a protective wall around the affected area.

What is electrospinning? “Polymers, solvents and other molecules are combined in ways that allow the resulting structures to be tuned. It’s a manufacturing technique that enables both nano- and microscale fibres to be interwoven, creating a high porosity and surface area that enables drugs to interact with the mouth, while also adhering to it.”

“Scientists at Sheffield University and Dermtreat A/S have developed an alternative to the ointments and mouthwashes currently used to treat ulcers and lesions inside the mouth. “

Lead author Dr Craig Murdoch, Oral Bioscience School of Clinical Dentistry, said: “Current treatments consist of using steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. The patch acts like a plaster inside your mouth, which means it is very effective at directly targeting the specific area as well as forming a protective barrier. Patients who have trialled the patch found it to be very comfortable to wear and they were really pleased with the length of adhesion which makes it particularly effective and efficient.”

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