Roche and Regeneron’s COVID-19 antibody mixture has shown positive results in its Phase III trial

Science

Roche and Regeneron’s COVID-19 antibody mixture has shown positive results in its Phase III trial, which assessed the investigational treatment in infected non-hospitalised patients.

The primary endpoint of the late-stage outcomes trial of imdevimab and casirivimab in high-risk, non-hospitalized COVID-19 patients was met, with a 70% reduction in the risk of death or hospitalisation at the 1,200mg IV dose level and a 71% reduction at the 2,400mg IV dose level.

“Roche and Regeneron’s COVID-19 antibody mixture has shown positive results in its Phase III trial.“

In addition, the antibody mixture met all critical secondary endpoints in the REGN-COV 2067 trial, including the ability to reduce symptom duration by a median of 4 days.

REGEN-COV20145, a companion phase 2 study in low-risk symptomatic or asymptomatic non-hospitalizedCOVID-19 patients, found substantial and comparable viral load reduction across a range of doses from 300 to 2,400mg.

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