Gene linked with cancer proliferation discovered

A new study has identified a gene which could play a key role in causing the abnormal molecular events which lead to the development of cancer.

Scientists at Barts and the London School of Medicine and Dentistry have found that high levels of the FOXM1 gene can cause excessive cell proliferation, which leads to the pre-cancer condition of hyperplasia.

Using adult human stem cells from the mouth and a 3D tissue culture model system, it was shown that cells expressing normal levels of FOXM1 did not experience the same excessive cell growth levels.

It is hoped that the discovery will lay the foundation for the future development of diagnostic tests to detect cancer at its earliest stages.

Dr Muy-Tek Teh of the Institute of Dentistry at Barts added: "Furthermore, understanding the origin of cancer initiation may unveil new research opportunities for finding effective anti-tumour drugs that stop or prevent cancer at its earliest incipient stage."

Earlier this week, findings were reported from a Cardiff University study that isolated a genetic target which could be used to boost bowel cancer survival rates.